Physiological Mapping of the Cerebral Cortex in Neuropathology

This book covers a new concept and unique approach named "Physiological Mapping" of the cerebral cortex in the rat's brain. The unique parameter that is used in the authors' studies is the monitoring, in vivo and in real time, of the mitochondrial NADH redox state. In addition, the monitoring of cerebral blood flow, tissue oxygen level, extracellular potassium ion and DC potential as well as ECoG is reported.
The main pathological event that was studied was cerebral ischemia that mimic the stroke developed in patients. Different models of ischemia were investigated by using the developed concept of "Physiological Mapping". A unique chapter in the book describes and discuss an event named "Metabolic Oscillations" that developed mainly in the ischemic brain. Also the role of nitric oxide in various pathophysiological conditions such as ischemia, hypoxia, and hypercapnia are discussed.